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Filter Cartridge


Membrane PVDF filter cartridges


LPSL Low Extractable and Longer Service Life Filter Cartridge for Plasma Fractionation

Materials of Construction


Double Layer Hydrophilic PES



Core, Cage and Drainage


End Caps

PP (222/226 with encapsulated stainless   steel reinforcing ring)



Sealing technology

Thermal Bonding, No Adhesives





5 inch, 10 inch, 20 inch, 30 inch

Filtration   Area, ft2

≥ 4.9 per 10-inch cartridge

Pore Size, μm


Maximum Differential Pressure

Forward: 4.2 bar @ 23 ℃; 1.5   bar @ 85 ℃

Integrity Test at 23 

Water bubble point

≥ 3500 mbar (50 psig)

Diffusive flow

≤ 30ml/min/10”@2.8bar

Bacterial Retention

Passed the bacterial   challenge testing using Brevundimonas diminuta
(ATCC19146) at a minimum challenge concentration of 1 x 107 CFU/cm2.

Extractables, per 10-inch cartridge

≤ 10 mg after 24-h soak in   water

Effluent Particle Level

Meets the requirements   of Chinese Pharmacopoeia 2010, Volume Ⅱ, appendix Ⅸ C.

Non-Fiber Releasing

Meets the criteria for   a “non-fiber releasing” filter as defined in 21 CFR 210.3 (b) (6).


Component materials   meet GB/T 14233.2<2005>of Chinese National
Standard for Safety Tests.


< 500 ppb after a water flush of 60 liters per 10-inch cartridge

Multiple Sterilization Cycles

40 steam-in-place sterilization or autoclave cycles of 30 min at 123℃

Oxidizable Substances

Meets the criteria of Chinese Pharmacopoeia 2010, volume Ⅱ for purified water.

Bacterial Endotoxins

< 0.25 EU/ml as determined by the LAL test

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LPSL filter cartridges are specially designed for sterilizing filtration of plasma fractionation. They are featuring extremely low extractables with no more than 10mg/10”, longer service life with 40 cycles of SIP. These filters can powerfully ensure final product quality.

● Cartridges produced in a controlled environment
● Manufactured according to ISO9001 certified Quality Management System

Ordering Information
LPSL Low Extractable and Longer Service Life Filter Cartridge for Plasma Fractionation

Features and Benefits
● Double layer hydrophilic PES Membrane
● Low protein binding
● Extensive drug compatibility for critical applications
● Extremely low extractables

Plasma Fractionation
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Sterile Injection Powder

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